Solution to make AdiIRC interface with screen readers.
Get adispeak alpha 0.3 from: https://github.com/fastfinge/adispeak/releases/download/v_0.3/adispeak_0.3.zip
Put everything in adispeak\bin\x64\release into the same folder as AdiIRC.exe. Run AdiIRC.exe, go to file, plugins, then load. Load adispeak.dll. It should work!
Have Visual Studio 2019. Do the obvious things; the project should come with everything you need!
The preconfigured adispeak/bin/x64/Release package includes AdiIRC config files that connect to irc.rblind.com and autojoin #main by default. It also ships a sounds folder wired into config.ini for AdiIRC's supported sound events, using short WAV files selected from Onj.zip.