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Screen antibody, TCR, and peptide sequences for developability liabilities — the motifs that cause deamidation, isomerization, fragmentation, unwanted glycosylation, oxidation, and cysteine problems.
Identifying potential liabilities in therapeutic antibody candidates using 3D structure analysis. Takes a protein structure in PDB format through preprocessing and liability detection to flag developability risks.
PhD project Github repository
Compute physicochemical properties (charge, GRAVY, pI, MW, ε) for peptide and antibody/TCR lead ranking
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