pk-pd

LLM-operated precision digitizer for biomedical graphs (PK/PD, dose-response, Kaplan-Meier, scatter/line/bar/box/forest, heatmaps, swimmer plots) with calibrated uncertainty and model fits.

A curated, citation-backed dataset of anesthetic and perioperative PK/PD model parameters featuring machine-enforced applicability envelopes, forward simulation, model-divergence visualization, and automated exports to standard pharmacometric formats like NONMEM, SBML, and Pumas.

R Shiny application for NONMEM workflows: create control streams, run NONMEM models, explore data and results, generate diagnostic plots and GOF, compare runs, and perform VPC, jackknife and sensitivity analyses.